Am.J Clin Nutr. View abstract. Kasuga, S., Uda, N., Kyo, E., Ushijima, M., Morihara, N., and Itakura, Y. Pharmacologic activities of aged garlic extract in comparison with other garlic preparations. View abstract. Gao, C. M., Takezaki, T., Ding, J. H., Li, M. S., and Tajima, K. Protective effect of allium vegetables against both esophageal and stomach cancer: a simultaneous case-referent study of a high-epidemic area in Jiangsu Province, China. Effects of a dried garlic preparation on fibrinolysis and platelet aggregation in healthy subjects. View abstract. Garlic might increase the breakdown of estrogen. Evans V. Herbs and the brain: friend or foe? Higashikawa, F., Noda, M., Awaya, T., Ushijima, M., and Sugiyama, M. Reduction of serum lipids by the intake of the extract of garlic fermented with Monascus pilosus: a randomized, double-blind, placebo-controlled clinical trial. Ince DI, Sonmez GT, and Ince ML. 2006;20(6):504-510. 2006;45(10):1161-1163. View abstract. View abstract. 2-20-2006;103(3):333-337. Aged garlic extract and its constituents inhibit Cu2+ -induced oxidative modification of low density lipoprotein. View abstract. View abstract. Pediatrics 1991;88:737-44. Cancer Epidemiol.Biomarkers Prev. A case-control study of gastric cancer and diet in Italy. Winter 2016;16(4):80-81. The Cochrane Library 2001;2. View abstract. 2-11-1999;42(3):364-372. View abstract. Early research suggests that taking garlic by mouth does not seem to reduce leg pain when walking due to poor blood flow in the legs. Narrowing of blood vessels that causes poor blood flow to the limbs (peripheral arterial disease). This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Int.J Cardiol. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination. Ann Intern Med 1993;119:599-605. Garlic taken by mouth in large doses may be harmful to children. Prostaglandins Leukot Essent Fatty Acids 1996;54(3):183-186. But it doesn't seem to work as well as D-penicillamine. View abstract. Rajan, T. V., Hein, M., Porte, P., and Wikel, S. A double-blinded, placebo-controlled trial of garlic as a mosquito repellant: a preliminary study. Bordia A. 1997;8(1):41-44. Huang, J., Frohlich, J., and Ignaszewski, A. P. The impact of dietary changes and dietary supplements on lipid profile. View abstract. View abstract. J Nutr 2001;131(3s):1027S-1031S. View abstract. View abstract. Egen-Schwind C, Eckard R, Jekat FW, and et al. Cohain, J. S. Long-term symptomatic group B streptococcal vulvovaginitis: eight cases resolved with freshly cut garlic. 2008;28(2):108-110. View abstract. Naganawa, R., Iwata, N., Ishikawa, K., Fukuda, H., Fujino, T., and Suzuki, A. Inhibition of microbial growth by ajoene, a sulfur-containing compound derived from garlic. 1990;29(1):75-76. J Nutr. View abstract. Sovova, M. and Sova, P. [Pharmaceutical significance of Allium sativum L. 4. Jalloh MA, Gregory PJ, Hein D, et al. Wohlrab, J., Wohlrab, D., and Marsch, W. C. Acute effect of a dried ethanol-water extract of garlic on the microhaemovascular system of the skin. View abstract. What’s more, the water soluble powder extract of garlic helps to stave off these side effects by limiting the amount of acid and its effect. 1999;141(2):391-392. But other population research suggests that consuming raw garlic can reduce the risk of lung cancer. View abstract. 4-30-2007;561(1-3):32-38. J Nutr. Vaes, L. P. and Chyka, P. A. Interactions of warfarin with garlic, ginger, ginkgo, or ginseng: nature of the evidence. J Nutr. Garlic juice and garlic oil, both are considered very potent … Baluchnejadmojarad, T., Roghani, M., Homayounfar, H., and Hosseini, M. Beneficial effect of aqueous garlic extract on the vascular reactivity of streptozotocin-diabetic rats. Does garlic alter the lipid pattern in normal volunteers? View abstract. Bespalov, V. G., Barash, N. I., Ivanova, O. View abstract. Hsing AW, Chokkalingam AP, Gao YT, et al. View abstract. In: Ohigashi H, Osawa T, Terao J, and et al. Jung, E. M., Jung, F., Mrowietz, C., Kiesewetter, H., Pindur, G., and Wenzel, E. Influence of garlic powder on cutaneous microcirculation. Simons LA, Balasubramaniam S, von Konigsmark M, et al. J Agric Food Chem 2007;55:1280-8. 2009;23(4):579-581. Am J Gastroenterol. According to the National Institutes of Health, bad breath and body odor are the most common side effects associated with garlic supplements. Br J Urol 1995;76(4):518. 1990;34(4):651-653. View abstract. Early research suggests that applying certain garlic extracts to corns on the feet twice daily might improve corns. Siegel G. Long-term effect of garlic in preventing arteriosclerosis - results of two controlled clinical trials. 2007;(179):347-362. Subramanian P, Sundaresan S, and Manivasagam T. Influence of garlic extract on temporal characteristics of lipid peroxidation products and antioxidants in tumor-bearing rats. Indian J Exp Biol 1992;30(6):523-526. Br J Clin Pract Suppl 1990;69:3-6. Farrell, A. M. and Staughton, R. C. Garlic burns mimicking herpes zoster. J Nutr 2001;131(3s):1006S-1009S. 2020;124(4):450-456. Augusti, K. T. and Sheela, C. G. Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin secretagogue, in diabetic rats. View abstract. Asia Pac.J Clin Nutr. Drug Dev.Ind.Pharm. Zhou XF, Ding ZS, Liu NB. Lack of efficacy of dried garlic in patients with hyperlipoproteinemia. Millen, A. E., Subar, A. F., Graubard, B. I., Peters, U., Hayes, R. B., Weissfeld, J. L., Yokochi, L. A., and Ziegler, R. G. Fruit and vegetable intake and prevalence of colorectal adenoma in a cancer screening trial. Garlic oil might decrease how quickly the liver breaks down some medications. View abstract. Side effects of allicin-containing supplements including diarrhea, heartburn, gas, and nausea. Antimicrob Agents Chemother 1986;30(3):499-501. Eur.J Obstet.Gynecol.Reprod.Biol. Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Indian J Dermatol.Venereol.Leprol. Le Marchand L, Hankin JH, Wilkens LR, et al. View abstract. Hajheydari, Z., Jamshidi, M., Akbari, J., and Mohammadpour, R. Combination of topical garlic gel and betamethasone valerate cream in the treatment of localized alopecia areata: a double-blind randomized controlled study. View abstract. Gender may affect the action of garlic oil on plasma cholesterol and glucose levels of normal subjects. October 2000. The effect of a garlic preparation on plasma lipid levels in moderately hypercholesterolemic adults. Chin Med J (Engl.) Arzneimittelforschung 1993;43:978-81. Warfarin (Coumadin) interacts with GARLIC. View abstract. Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase. Challier, B., Perarnau, J. M., and Viel, J. F. Garlic, onion and cereal fibre as protective factors for breast cancer: a French case-control study. View abstract. JAMA 2000;284:831. View abstract. Mukherjee, M., Das, A. S., Das, D., Mukherjee, S., Mitra, S., and Mitra, C. Role of oil extract of garlic (Allium sativum Linn.) Eming, S. A., Piontek, J. O., Hunzelmann, N., Rasokat, H., and Scharffetter-Kachanek, K. Severe toxic contact dermatitis caused by garlic. Altern.Ther Health Med 2007;13(4):22-28. Clin Exp Pharmacol Physiol 1995;22:414-7. View abstract. Clin Infect Dis 2002;34:234-8. A., Prianishnikov, V. V., Kunnova, L. M., Rabinovich, E. A., and Orekhov, A. N. [Allicor efficacy in lowering the risk of ischemic heart disease in primary prophylaxis]. Meher S, Duley L. Garlic for preventing pre-eclampsia and its complications. 2008;27(1):55-63. anonymous. AHRQ Publication No. Borrelli F, Capasso R, Izzo AA. View abstract. The body breaks down the estrogen in birth control pills to get rid of it. BMJ 2019;366:l5016. 20 (Contract 290-97-0012 to the San Antonio Evidence-based Practice Center based at The University of Texas Health Science Center at San Antonio and the Veterans Evidence-based Research, Dissemination, and Implementation Center, a Veterans Affairs Health Services Research and Development Center of Excellence). Eur J Clin Res 1996;8:30-32. Phytother.Res. View abstract. View abstract. Nutr.Cancer 2002;42(2):241-247. Clin Investig 1993;71:383-6. Koscielny J, Klussendorf D, Latza R, and et al. Corns. Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Ascherio A, and Willett WC. Garlic ingestion by pregnant women alters the odor of amniotic fluid. 1995;132(1):161-162. Garlic products sold as health supplements may vary widely in amount of allicin, the active ingredient in garlic. Hsu, C. C., Huang, C. N., Hung, Y. C., and Yin, M. C. Five cysteine-containing compounds have antioxidative activity in Balb/cA mice. Dixit, V. P. and Joshi, S. Effects of chronic administration of garlic (Allium sativum Linn) on testicular function. Effect of aged garlic extract on APP processing and tau phosphorylation in Alzheimer's transgenic model Tg2576. Chiavarini M, Minelli L, Fabiani R. Garlic consumption and colorectal cancer risk in man: a systematic review and meta-analysis. Peleg, A., Hershcovici, T., Lipa, R., Anbar, R., Redler, M., and Beigel, Y. Ernst E. Can allium vegetables prevent cancer? View abstract. Ann Ital Dermatol Clin Sperimentale 1994;48:120-121. Hu, J., Nyren, O., Wolk, A., Bergstrom, R., Yuen, J., Adami, H. O., Guo, L., Li, H., Huang, G., Xu, X., and . Fleischer S, Bayerl C, and Jung EG. View abstract. Efendy JL, Simmons DL, Campbell GR, Campbell JH. 2003;51(3):593-597. View abstract. Rahmy, T. R. and Hemmaid, K. Z. Prophylactic action of garlic on the histological and histochemical patterns of hepatic and gastric tissues in rats injected with a snake venom. Circulation 1997;96:2649-55. Handb.Exp.Pharmacol. View abstract. Common side effects (especially when eating raw garlic) may include: heartburn, burning in your mouth or throat; This is not a complete list of side effects and others may occur. Phytomedicine 1999;6:125-31. 2000;95(1):309. View abstract. Takeuchi, S., Matsuzaki, Y., Ikenaga, S., Nishikawa, Y., Kimura, K., Nakano, H., and Sawamura, D. Garlic-induced irritant contact dermatitis mimicking nail psoriasis. Research suggests that taking garlic daily for 7 days does not benefit people with scleroderma. Odorless garlic is less likely to cause halitosis, or bad breath. [Epub ahead of print] View abstract. Zhou, Y., Zhuang, W., Hu, W., Liu, G. J., Wu, T. X., and Wu, X. T. Consumption of large amounts of Allium vegetables reduces risk for gastric cancer in a meta-analysis. View abstract. 11 Bad for liver. Lau BH, Lam F, Wang-Cheng R, and et al. Life Sci. Research with other products containing garlic, alone or along with other ingredients (Kyolic Reserve, Kyolic, Total, High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). View abstract. View abstract. View abstract. View abstract. Hansanugrum, A. and Barringer, S. A. When it comes to garlic side effects it is usually only mentioned that it causes bad breath. Anti-atherosclerotic therapy based on botanicals. 2001;10(2):137-165. Ann Pharmacother 2000;34(12):1478-1482. Mycoses 1996;39:393-5. View abstract. View abstract. Andrianova, I. V., Ionova, V. G., Demina, E. G., Shabalina, A. Warfarin (Coumadin) is used to slow blood clotting. Aged garlic extract reduces left ventricular myocardial mass in patients with diabetes: A prospective randomized controlled double-blind study. Foster BC, Foster MS, Vandenhoek S, et al. 1991;37:85-88. Int J Cardiol 2013;168(3):2310-4. 1998;14(8):737-747. Some research has found that eating more garlic is linked with a reduced risk of colon or rectal cancer. Isaacsohn JL, Moser M, Stein EA, et al. 2003;15(3):120-129. Zhang Y, Moriguchi T, Saito H, Nishiyama N. Functional relationship between age-related immunodeficiency and learning deterioration. Buhshan S, Sharma SP, Singh SP, and et al. Biochem Soc.Trans. However, garlic has other negative features that can cause serious harm to health. Also avoid using garlic together with other herbal/health supplements that can also affect blood-clotting. De Santos O and Grunwald J. Singh, B. Z., and Li, B. Allitridum mimics effect of ischemic preconditioning by activation of protein kinase C. Acta Pharmacol.Sin. Treatment of venous ulcers with the herbal-based ointment Herbadermal(R): a prospective non-randomized pilot study. Toxicology 1999;132:215-25. 2003;75(3):53-56. Gardner CD, Lawson LD, Block E, et al. Herbal Medicine Expanded Commission E Monographs. Br.J Cancer 1979;39(3):293-309. Since allicin may also increase the risk of bleeding, it's crucial to avoid allicin-containing supplements prior to undergoing surgery. Garlic and honey have been used in traditional medicines around the world. Some research suggests that eating more garlic does not prevent the development of lung cancer. You should not use garlic if you are allergic to it. 2020;19(2):1468-1471. J Orthomolec Med 1987;2(1):15-21. Int J STD AIDS. Obesity. J Med Food 2005;8(3):319-326. View abstract. Int J Cancer 10-15-1989;44(4):611-616. View abstract. Select one or more newsletters to continue. View abstract. Effect of a combined supplementation of fish oil (MEGA-3) with garlic pearls on the serum lipid profile, blood pressure and body mass index of hypercholesterolemic subjects. Oi, Y., Kawada, T., Shishido, C., Wada, K., Kominato, Y., Nishimura, S., Ariga, T., and Iwai, K. Allyl-containing sulfides in garlic increase uncoupling protein content in brown adipose tissue, and noradrenaline and adrenaline secretion in rats. 2010;17(1):17-19. J Tradit.Chin Med 2000;20(4):243-246. Eur J Pharmacol 2001;433:177-85.. View abstract. Nutr Cancer. View abstract. Garlic (Allium sativum L.): adverse effects and drug interactions in humans. Parish, R. A., McIntire, S., and Heimbach, D. M. Garlic burns: a naturopathic remedy gone awry. Russell, J. E. Chinese complementary therapy for stress causing bilateral chemical burns to the feet. Pediatrics 1993;91:658-9. Some early research suggests that taking garlic oil macerate does not improve lung function, symptoms, or the need for antibiotics in children with cystic fibrosis. Phytother.Res. 2010;45(4):356-362. Chest pain (angina). View abstract. View abstract. J Ethnopharmacol. View abstract. View abstract. View abstract. McNulty, C. A., Wilson, M. P., Havinga, W., Johnston, B., O'Gara, E. A., and Maslin, D. J. Science 1997;278(5338):581. Phytother Res 2000;14(3):215-217. 2020;13:2389-2397. This survey is being conducted by the WebMD marketing sciences department. Garlic might slow blood clotting. Heart 2000;83(suppl 2):A4. Warshafsky S, Kamer RS, Sivak SL. View abstract. A pilot study. J Natl.Cancer Inst. Lian Z, Jun-Ling M, and Wei-Dong L. A randomized multi-intervention trial to inhibit gastric cancer in Shandong (progress report). 2006;20(1):21-27. View abstract. Effects of Allium sativum (garlic) on systolic and diastolic blood pressure in patients with essential hypertension. Early research on the use of garlic for preventing lung cancer is unclear. View abstract. A., and Pinto, P. L. [Treatment of ascaridiasis with garlic (Allium sativum)]. Am J Clin Nutr 1997;65:445-50. People who eat more garlic seem to have improved hand strength compared to those who don't eat garlic. Planta Med 1985;(5):460-461. By addressing inflammation, cellular mutation, and oxidative stress, garlic powder helps you lower your risk of cancer without any side effects. Stabler, S. N., Tejani, A. M., Huynh, F., and Fowkes, C. Garlic for the prevention of cardiovascular morbidity and mortality in hypertensive patients. Ried K, Frank OR, Stocks NP, et al. View abstract. Effects garlic on aerobic performance. Sumioka I, Matsura T, Yamada K. Therapeutic effect of S-allylmercaptocysteine on acetaminophen-induced liver injury in mice. Chu, T. C., Han, P., Han, G., and Potter, D. E. Intraocular pressure lowering by S-allylmercaptocysteine in rabbits. Phytother.Res 2000;14:200-2. 2003;3(10-11):1483-1489. Some early research suggests that taking garlic powder might help to reduce levels of lead in the blood. 2015;28(3):414-23. View abstract. View abstract. View abstract. Dermatology 1996;192(4):373-374. View abstract. Vorberg G, Schneider B. Gebhardt R, Beck H. Differential inhibitory effects of garlic-derived organosulfur compounds on cholesterol biosynthesis in primary rat hepatocyte cultures. Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women. Adv.Ther 2007;24(5):1146-1153. Consumption of aqueous garlic extract leads to significant improvement in patients with benign prostate hyperplasia and prostate cancer. J Med Assoc Thai. Treatment of hyperlipidaemia with garlic-powder tablets. 2009;22:39-48. Khodavandi, A., Alizadeh, F., Harmal, N. S., Sidik, S. M., Othman, F., Sekawi, Z., and Chong, P. P. Expression analysis of SIR2 and SAPs1-4 gene expression in Candida albicans treated with allicin compared to fluconazole. Planta Med 1994;60(3):214-217. An unusual garlic burn occurring on an unexpected area. Nature 10-14-1999;401(6754):629. It is also less likely to cause the pungent, sulfurous body odor classicall… Some medications are changed and broken down by the liver. View abstract. 2001;22(2):132-136. A commentary on the effects of garlic extraction and formulation on product composition. J Nutr. Br J Clin Res 1995;6:91-100. Jain, R. C. Anti tubercular activity of garlic oil. J Am Acad.Nurse Pract. View abstract. View abstract. 3-21-2012;104(6):488-492. Ip C, Lisk DJ. J.Dermatol. Planta Med 1997;63:263-264. Mennella JA, Johnson A, Beauchamp GK. View abstract. View abstract. 2010;19(4):1089-1097. View abstract. Pharmaceutical Care and Research (Yaoxue Fuwu Yu Yanjiu) (CHINA) 2002;2:122-124. Epidemiology 1997;8:658-65. View abstract. View abstract. 2005;77(12):9-13. Gurley BJ, Gardner SF, Hubbard MA, et al. Eur.J.Emerg.Med. J Egypt.Soc Parasitol. View abstract. Bordia, A. K., Joshi, H. K., Sanadhya, Y. K., and Bhu, N. Effect of essential oil of garlic on serum fibrinolytic activity in patients with coronary artery disease. Eguchi, A., Murakami, A., and Ohigashi, H. Novel bioassay system for evaluating anti-oxidative activities of food items: use of basolateral media from differentiated Caco-2 cells. Mechanism of antioxidation, inhibiting carcinogenesis and modification of LDL of aged garlic extract. View abstract. View abstract. Also, applying a garlic gel with 1% ajoene seems to be about as effective as antifungal cream for treating athlete's foot. Allium vegetables and risk of prostate cancer: a population-based study. View abstract. However, research has shown that garlic may not be effective in treating these conditions. Gallwitz, H., Bonse, S., Martinez-Cruz, A., Schlichting, I., Schumacher, K., and Krauth-Siegel, R. L. Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies. Adler A, Holub BJ. Zhang XH, Lowe D, Giles P, et al. Nutr Cancer. Aged garlic extract improves endothelial function in men with coronary artery disease. Phytomedicine 2018;48:70-5. doi: 10.1016/j.phymed.2018.04.060. 2012;36(5):439-444. Ide N, Nelson AB, and Lau BHS. Rafaat, M. and Leung, A. K. Garlic burns. View abstract. The name garlic is derived from an Old English word – Garleac, which means spear leek. Wiad.Lek. Graham DY, Anderson SY, Lang T. Garlic or jalapeno peppers for treatment of Helicobacter pylori infection. J Med Food 2008;11(3):582-586. Athlete's foot (Tinea pedis). Antimicrob.Agents Chemother 1985;27(4):485-486. A pregnancy complication marked by high blood pressure and protein in the urine (pre-eclampsia). J Appl.Bacteriol. View abstract. Systemic contact dermatitis from diallyl disulfide. 2006;84(4):912-919. Prostaglandins Leukot Essent Fatty Acids 2000;62:55-73. View abstract. Nutrition 2013;29(1):71-75. Garlic is a commonly used food and flavoring agent. View abstract. 2016;32(1):33-40. Shu, X. O., Zheng, W., Potischman, N., Brinton, L. A., Hatch, M. C., Gao, Y. T., and Fraumeni, J. F., Jr. A population-based case-control study of dietary factors and endometrial cancer in Shanghai, People's Republic of China. Some birth control pills include ethinyl estradiol and levonorgestrel (Triphasil), ethinyl estradiol and norethindrone (Ortho-Novum 1/35, Ortho-Novum 7/7/7), and others. J Nutr 2001;131(3s):1058S-1060S. Leelarungrayub, N., Rattanapanone, V., Chanarat, N., and Gebicki, J. M. Quantitative evaluation of the antioxidant properties of garlic and shallot preparations. 2006;84(6):1324-1329. View abstract. View abstract. When taken by mouth, garlic can cause bad breath, a burning sensation in the mouth or stomach, heartburn, gas, nausea, vomiting, body odor, and diarrhea. View abstract. View abstract. Khodavandi, A., Alizadeh, F., Harmal, N. S., Sidik, S. M., Othman, F., Sekawi, Z., Jahromi, M. A., Ng, K. P., and Chong, P. P. Comparison between efficacy of allicin and fluconazole against Candida albicans in vitro and in a systemic candidiasis mouse model. An, Sobenin IA, Korneev NV, et al Insect Repellant nystatin, but other research.. Cf, Levin MB Sci 2009 ; 12 ( 3 ):183-186 and... Wang, B Aruna V, Castanho, R. J., Shi, Z. X., Wang L Fabiani... Mit einem Knoblauch-Lezithin-Präparat ):1478-1482 I. C. Sporotrichosis treated with garlic ( Allium sativum Linn ) on testicular.. Burn occurring on an unexpected area chemical burn caused by local application of on... Affect blood-clotting and may increase your risk for cancer of the stomach ( gastritis ) world! 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